NailScan runs fast profile HMM searches with nail (Nail is an Alignment Inference tooL) against InterPro member databases—by default Pfam, NCBIfam, SUPERFAMILY, PANTHER, and Gene3D. Nail uses MMseqs2 for seeding and approximates the HMMER3 Forward/Backward algorithm, so throughput is much higher than a plain HMMER3 scan on the same libraries.
NailScan is not InterProScan and is not intended to reproduce identical InterProScan calls; it targets scalable HMM-based domain annotation where speed matters, with post-processing aimed at InterProScan-like filtering. It remains under development and is not affiliated with nail, InterPro, or the member databases. Quick start, install.sh, batch/single shell wrappers, supported DBs, and benchmark notes are in the NailScan repository.